Biomarker Panel to Predict Type 1 Diabetes

Raghu Mirmira, Professor of Pediatric Diabetes, Indiana University School of Medicine

Chapters:

0:00 Diabetes today

3:59 Biomarker panel to predict Type 1 diabetes

7:16 Using digital PCR to identify death of beta cells

11:41 Future of diabetes treatment

When we talk precision medicine on Mendelspod, we’re usually talking about oncology. But today we shift our focus to diabetes.

Raghu Mirmira is an MD PhD at Indiana University who is working on a panel of biomarkers that would predict Type 1 diabetes. That’s right. Predict.

Having already found a DNA biomarker candidate which detects dying beta cells using the new technology of digital PCR, Raghu is now working to improve the panel with other metabolites.

Will we some day have a Myriad Genetics for diabetes? Raghu says, yes. But he warns that we must also develop new treatment options to go along with a predictive blood test.

“Before we get to the point where this is a commercially available test, we need to be doing further studies to figure out what’s the outcome of individuals who test in a particular way. And what kind of interventions could improve those outcomes in some way.”




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