Chris Anzalone, CEO of Arrowhead Pharmaceuticals
0:00 Why has it taken so long with RNAi?
3:12 First RNAi program to go outside the liver
6:32 Which diseases are you focusing on?
10:12 The delivery problem
15:26 How will we know when the field has matured?
Fifteen years ago, folks in the industry were buzzing about RNAi the way they talk about CRISPR today. Then things went quiet for the technology, at least in the news. Until last year.
In September of 2017, Alnylam Pharmaceuticals, the leader in the RNAi space, announced such positive phase III study results that most experts in the business expect an FDA approval soon. It will be the first for an RNAi drug.
So what took the technology so long, and what was the key to the great results? These are questions we ask today of Chris Anzalone, the CEO of Arrowhead Pharmaceuticals, another runner in the RNAi race. Arrowhead scooped up various RNAi programs from some of the big pharma giants, including Roche and Novartis, during the "quiet" years. Coupling these assets with some of their own technology, they are going after not just some of the esoteric diseases we've come to expect from a new platform first proving itself, but are also targeting the very recognizable Hepatitis B.
How does Arrowhead plan to further differentiate themselves from Alnylam?
“One of our great contributions to the field and, frankly, to world health, is our ability to bring this outside the liver,” says Chris.
So far, the major programs from RNAi companies like Alnylam are all limited to liver diseases. Arrowhead is the first to have drug candidates which go after non-liver diseases. It's a major step forward for this RNAi technology.
How we will know when RNAi has matured, we ask Chris at the end.