Transitioning to scientific independence from the tribal world of government-sponsored biomedical research is not easy. The stars have to align in your personal life. For example, having a supportive spouse who will quit their job and move across the country with you. Alas, searing curiosity alone cannot pay the bills. You’ll need a day job, or better yet a complementary, part-time consulting gig that leaves you enough time to do professional-grade science. Even after all that, you’ll still need a place to do the experiments – and of course a way to pay for it.