COVID


DNA Script Takes DNA Synthesis Back to the Bench with Enzymatic Tech: Thomas Ybert, CEO

DNA is a multibillion-dollar industry in 2021 and satisfies many life science applications, including drugs, reagents, siRNA, PCR, diagnostics, synthetic biology, and many others. Enzymatic DNA synthesis, or EDS, is a new approach to manufacturing DNA that is much more efficient and user-friendly and could disrupt the current market.

Thomas Ybert is the CEO of DNA Script which is out with a new benchtop enzymatic DNA synthesizer called SYNTAX. He says in contrast to old chemical synthesizers, the new “DNA printer” takes virtually no expertise to run and will return much of the current business from service back to the old model where biologists make their own, having the power to “go from design to results in less than 24 hours.”

“[Biologists] are programming biological systems. DNA is the programming code. And you want this design-build-test cycle to go as fast as possible. It’s very clear that the next revolution will be from the life sciences. And we want to enable people to design-build-test super quickly.”

Investors appear happy with the company, just pouring in $165 million last month. The SYNTAX system is available now. With all that hassle of chemical synthesis cleared away by this new easy-to-use technology, will researchers and others return to making their own DNA?

A New Way to Phenotype Life: Chris Mason Talks Spatial Biology, His New Book

Chris Mason, Professor of Physiology and Biophysics and prolific genomics researcher at Weill Cornell Medicine, joins us to talk about what he’s doing with the new generation of spatial biology tools.

The first papers we dive into are his work on COVID. Chris says the spatial tools have shown us the ravages of the coronavirus on the body like nothing we’ve seen before, i.e. the tissue damage from the cytokine storms and “the long term perturbations such as seeing cells far apart that were usually hanging out together.”

Does this new resolution open up all kinds of questions for not just the SARS-CoV-2 virus, but for other viruses Chris has long studied? And does he think the pandemic will spark an “age of virology” research?

Chris says he’s using the new spatial tools in his work with NASA as well as his grander metagenomics projects and believes the companies making these new tools are "just getting started."

Speaking of space, Chris has a new book out this summer into which he has poured much of his vast knowledge of genomics and science, his hope for our species, and a personal plea. It’s called, The Next 500 Years: Engineering Life to Reach New Worlds.  Go check it out.

And check out our sponsor links as well. Thanks to NanoString for underwriting this new series.



mendelspod

New to Mendelspod?

We advance life science research, connecting people and ideas.
Register here to receive our newsletter.

or skip signup