PregSource: The NIH’s Crowdsourcing Project for Pregnancy Data with Caroline Signore

There are hundreds of pregnancy apps available. So what is unique about the NIH’s new crowdsourcing project called PregSource?

“We think PregSource is different because we offer the security and reliability of having been developed at the NIH with the participation of well regarded organizations. We’ve developed the content with expert input at every stage. Their are no ads at PregSource. And, of course, we will never, ever share or sell the data with a commercial organization.”

That's Caroline Signore, Principal Investigator at PregSource who says the project began in November of 2017 out of the need for data on typical pregnancies. There was a lot of research and attention, she says at the outset of today’s show, on pregnancy problems, but there has been a big lack of understanding on normal pregnancy with women in the current age. 

PregSource is for any pregnant woman at any stage, and commitment can be at various levels. How does the site incentivize women to share their data and stay committed?

Importantly, data from the site will be available for researchers. What goals does Caroline have for the site in this direction? How will she define success for PregSource?

DTC Genomics: Opportunity Lost?

Once I warmed up to the idea of startup companies offering to sequence the DNA of anyone capable of ordering from, I began to look forward to what might come of this nascent industry. Enabling individuals to have their DNA sequenced certainly seemed like an out-of-the-box idea at the time and I wondered if a so-called paradigm shift might arise from placing genetic information, unfiltered and unadvised, in the hands of its owner.

I had(and still have) two chief hopes for "paradigm shifts" that might come from throwing the genetics box wide open:

Clinical Trials and Social Media with Craig Lipset, Pfizer

Podcast Sponsor: The Scientific Services Marketplace


Craig Lipset, Pfizer Bio and Contact Info

Bridging Listen (5:48) Bridging clinical research with eHealth

<img src="/images/speaker.jpg" alt=What happens when trial patients connect with each other online?"/> Listen (2:09) What happens when trial patients connect online?

How have patients changed Listen (4:01) How have patients changed?

What has Pfizer changed Listen (2:51) What has Pfizer changed?

Challenges with mobile health Listen (4:09) Challenges with mobile health?

How is Pfizer using social media Listen (4:58) How is Pfizer using social media?

Social media guidance Listen (9:44) Social media guidance

Pfizer and innovation Listen (1:28) Pfizer and innovation

Clinical trials in 5 years Listen (5:14) Clinical trials in 5 years

We talk with Craig Lipset of Pfizer about how social media is changing clinical trials. Craig has good support at Pfizer to launch innovative trial programs. At Pfizer he is bridging clinical research with eHealth technologies and exploring the opportunity to further inform and empower both patients and providers in the age of social media. Craig served as Vice President of Program Management at Adnexus Therapeutics and was part of the founding management team for Perceptive Informatics. He is the 2010 recipient of the DIA's Outstanding Service Award.

Open Science Summit 2011

Podcast Sponsor:, Phenotypic surveys


Joseph Jackson, Organizer, Open Science Summit Bio and Contact Info

Why open science for you? Listen (3:37) Why open science for you?

2nd Open Science Summit Listen (6:03) 2nd Open Science Summit

The future (or end) of IP Listen (8:49) The future (or end) of IP

Does open science mean free science? Listen (8:02) Does open science mean free science?

Put failures online as well Listen (6:37) Put failures online as well

A matter of when to publish Listen (5:09) A matter of when to publish

Obstacles to open science Listen (4:50) Obstacles to open science

Dr. Tomasz Sablinski, Founder, Transparency LS Bio and Contact Info

Crowdsourcing clinical trials Listen (9:32) Crowdsourcing clinical trials

Company objective Listen (5:20) Company objective

Advantages to open method Listen (6:01) Advantages to open method

Process Listen (3:03) Process

Is this the future? Listen (4:41) Is this the future?

'Open science' is a term frequently used in the life science community today. In an interview with KQED in San Francisco, open science evangelist Joseph Jackson says, “in the long run, open science will transform the way science is done, enhancing the best aspects of science while helping correct potential abuses and distortions." Mr. Jackson is the organizer of the 2nd Open Science Summit taking place in Mountain View CA Oct 22-23. He’s a co-founder of BioCurious, a community lab in Sunnyvale and co founder of LavaAmp, maker of an inexpensive, pocket size pcr machine. I am pleased to have Joseph and Dr. Tomasz Sablinski, a speaker at the conference, on the program today to talk about the upcoming summit.

Crowdsourcing phenotype -

Podcast Sponsor:

Open Science Summit, Oct 22-23, Mountain View, CA Register Today


Michael Simpson, CEO,, Bio and Contact Info

Zack Simpson, Chief Architect,, Bio and Contact Info

Phenotypic data not easy to get your arms around Listen (3:06) Phenotypic data not easy to get your arms around

How is a wiki better than current situation? Listen (4:39) How is a wiki better than current situation?

Who uses the site? Listen (4:31) Who uses the site?

Site like the perfect spouse Listen (7:42) Site like the perfect spouse

Anonymity crucial Listen (10:32) Anonymity crucial

Quality of data Listen (5:08) Quality of data

Connection to personalized medicine Listen (6:06) Connection to personalized medicine

We’re joined today by a team of brothers, Michael and Zack Simpson, to talk about their new website, Traitwise is a wiki for phenotypic data. Matching up this kind of data with a person’s genomic data has become a major goal of Personalized Medicine.