personalized medicine

Best of mendelspod - Highlights 2011

Podcast Sponsor: Ingenuity- iReport: The fastest way to get meaning from your expression data

Listen (3:50) Steve Burill: New Model for Big Pharma

Listen (7:06) Dan Vorhaus: The Myriad Case

Listen (3:36) Russ Altman: Personal Genomics and Patent Law

Listen (3:43) Mike Snyder: Million Dollar Interpretation

Listen (2:50) Howard McLeod: PGENI

Listen (2:08) Jonathan Eisen: Why Open Science?

Listen (3:12) George Church: Scientists and the Public

Listen (4:25) Ron Davis: Fit Between University and Industry

Listen (3:01) Greg Scott-Will China Soon Have a Steve Jobs?

As we approach the last day of 2011, we thought we’d look back and bring you highlights of the year, the very best of mendelspod. Included in today’s show are snippets from industry leaders on personalized medicine, the evolution of big pharma, gene patents, and thoughts on open science.

NOTE: It’s important to acknowledge that mendelspod has been made possible through the generous support of our sponsors throughout the year. We thank all of them for their partnership. We wish them and all of you a very happy holiday.

PMWC 2012: A Preview with Dr. Larry Marton

Podcast Sponsor: Singulex- Watch our cardiovascular monitoring programs explained on YouTube

Guest:

Dr. Laurence Marton, Program Committee Chairman, PMWC 2012 Bio and Contact Info

Theme-Road to Commercialization Listen (7:24) Theme-Road to Commercialization

Difference from Previous Conferences Listen (8:36) Difference from Previous Conferences

Industry Has Reached a Point of Exponential Growth Listen (4:05) Industry Has Reached a Point of Exponential Growth

Genesis for PMWC Listen (2:28) Genesis of PMWC

There are several conferences on Personalized Medicine each year. Perhaps the best attended is the Personalized Med World Conf taking place in Mountain View California, on Jan 23-24. We invited an advisor to the conference, Dr. Larry Marton, to speak to us about the focus of the upcoming show and what we can expect from this year’s lineup.

Dr. Marton is an advisor to the Personalized Medicine World Conference and joins us now to preview the upcoming conference. Dr. Marton serves as a consultant to industry and to governmental, not-for-profit, and academic institutions. Before moving from academia to industry, Dr. Marton was Dean of the University of Wisconsin-Madison Medical School and previously Chaired the Department of Laboratory Medicine at UCSF.

Personalized Medicine with Mike Snyder

Podcast Sponsor:

Open Science Summit, Oct 22-23, Mountain View, CA Register Today

Guest:

Dr. Mike Snyder, Director, Stanford Center for Genomics and Personalized Medicine, Bio and Contact Info

Stanford's Center for Genomics and PM Listen (5:06) Stanford's Center for Genomics and PM

Quality of Data Listen (10:05) Quality of Data

Thousand dollar genome, million dollar interpretation Listen (5:38) Thousand dollar genome, million dollar interpretation

Not just genomics Listen (6:35) Not just genomics

Why back at Stanford Listen (1:27) Why back at Stanford

Future of Personalized Medicine Listen (2:36) Future of Personalized Medicine

Michael Snyder is the Director of the Center of Genomics and Personalized Medicine at Stanford. Dr. Snyder is a leader in the field of functional genomics and proteomics. His laboratory study was the first to perform a large-scale functional genomics project in any organism.

Crowdsourcing phenotype - Traitwise.com

Podcast Sponsor:

Open Science Summit, Oct 22-23, Mountain View, CA Register Today

Guests:

Michael Simpson, CEO, Traitwise.com, Bio and Contact Info

Zack Simpson, Chief Architect, Traitwise.com, Bio and Contact Info

Phenotypic data not easy to get your arms around Listen (3:06) Phenotypic data not easy to get your arms around

How is a wiki better than current situation? Listen (4:39) How is a wiki better than current situation?

Who uses the site? Listen (4:31) Who uses the site?

Site like the perfect spouse Listen (7:42) Site like the perfect spouse

Anonymity crucial Listen (10:32) Anonymity crucial

Quality of data Listen (5:08) Quality of data

Connection to personalized medicine Listen (6:06) Connection to personalized medicine

We’re joined today by a team of brothers, Michael and Zack Simpson, to talk about their new website, Traitwise.com. Traitwise is a wiki for phenotypic data. Matching up this kind of data with a person’s genomic data has become a major goal of Personalized Medicine.

Taking Pharmacogenomics to the Rest of the World: Howard McLeod

This podcast was originally aired on Sept. 14th, 2011

Sponsored by: BioConference Live

Guest:

Dr. Howard McLeod, Director, PGENI, Bio and Contact Info

PGENI - Pharmacogenomics for Every Nation Initiative Listen (8:13) PGENI - Pharmacogenomics for Every Nation Initiative

Piggybacking on HIV education around the world Listen (2:27) Piggybacking on HIV education

Eight active centers around the world Listen (7:56) Eight active centers around the world

Examples of pharmacogenomics Listen (5:25) Examples of pharmacogenomics

FDA coming aboard Listen (3:25) FDA coming aboard

PGI at UNC: an interdisciplinary approach Listen (2:03) PGI at UNC: an interdisciplinary approach

The promise of lowering healthcare costs Listen (3:44) The promise of lowering healthcare costs

Other ways to use the genome Listen (3:44) Other ways to use the genome

Our guest today is Dr. Howard McLeod, an internationally recognized expert in pharmacogenomics. He’s the director for the UNC Institute for Pharmacogenomics and Individualized Therapy. He’s a member of the FDA’s subcommittee on Clinical Pharmacology, and is the director of the new PGENI, or Pharmacogenomics for Every Nation Initiative. Howard feels he has reached the highest career positions possible and now works to move along the field of pharmacogenomics in the best way possible.

George Church Talks Personalized Medicine and Synthetic Biology

This podcast originally aired on May 25th, 2011

Sponsored by: BioConference Live

Guest: Church George, PhD, Professor of Genetics, Harvard Medical School and Professor of Health Sciences & Technology, Harvard and MIT. Bio and Contact Info

Part I-Personalized MedicineChurch George Listen (20:24)

Part II-Synthetic BiologyChurch George Listen (19:04)

Part III-Personal AnecdotesChurch George Listen (06:54)

Our guest for the hour is Dr. George Church from Harvard. Dr. Church’s accomplishments are legendary among scientists in his field and beyond. His Ph.D. from Harvard in biochemistry and molecular biology with Wally Gilbert included the first direct genomic sequencing method in 1984. In 1994, the technology transfer of automated sequencing and software to Genome Therapeutics Corp. resulted in the first commercial genome sequence (the human pathogen, H. pylori). He was then involved in initiating the Human Genome Project as a Research Scientist at Biogen Inc. In 2006 he initiated the Personal Genome Project with the aim of advancing the field of Personalized Medicine. He invented the broadly-applied concepts of molecular multiplexing and tags, homologous recombination methods, and array DNA synthesizers. He has served in advisory roles for 12 journals and 5 granting agencies and also been involved in 22 private companies including LS9-which focuses on bio-petroleum, and Knome who provides full human genome sequencing. Current research focuses on integrating biosystems-modeling with personal genomics and synthetic biology.

Personalized Medicine World Conference 2011

This week I attended the 3rd annual World Conference for Personalized Medicine held at Microsoft’s Computer Science Museum in Mountain View, California. A museum for the history of computing seemed appropriate for a new industry which has been dramatically impacted by the accelerating pace of technological innovation. The most oft quoted theme in the conference: that the price of sequencing an entire genome has dropped at breathtaking speed over the last few years. Just four years ago, the price for a genome sequence hovered in the tens of millions of dollars.




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